Use of inequality operators in SQL queries force databases to use table scans to evaluate the inequalities. These queries generate high I/O if they run regularly against large tables. You should avoid SQL query that is using expression with NOT in it. If these queries must be run, then restructure the queries to eliminate the NOT keyword or operator. Instead of using:
SELECT * FROM MyTable WHERE col1 != 'value'
SELECT * FROM MyTable WHERE col1 < 'value' or col1 > 'value'