Question:
How can I configure Exchange Server for simple automatic replies when e-mails are sent to a specific account?

Answer:
The easiest way to do this is to log in once with an Outlook client using a profile configured for the mailbox you want the replies to come from. Set up the “Out of Office Assistant” to send your automatic replies and turn it on.

You can then log out and from that point on any messages that come to that mailbox should receive your auto-reply.

If you want these messages to go to Internet correspondents as well, you’ll need to check the Internet Mail Service Connector on your Exchange server and make sure it’s configured to allow automatic replies to the Internet.